795 Line-field confocal optical coherence tomography compared with confocal laser scanning microscopy: A pilot study on three different age groups

The aim of this work was to evaluate the performances recently developedin vivo imaging device Line-Field Confocal Optical Coherence Tomography (LC-OCT, DAMAE Medical) compared Laser Scanning Microscopy (CLSM, Vivascope 1500, Mavig) from a qualitative point view and assessment epidermal thickness according age. We conducted mono-centric open-label study. A total 17 subjects divided into three groups (3–6 months, 5–7 years 20–25 years) were recruited. Acquisitions have been performed on volar forearm. CLSM allows horizontal plane visualization. LC-OCT horizontal, vertical, three-dimensional visualization with better resolution in vertical axis, wider field faster image acquisition CLSM. Full epidermis calculated as mean value between surface dermo-epidermal junction reconstruction for LC-OCT. both devices allow at cellular level. Results obtained give slight decrease full This result is accordance previous study using classical OCT but differs those without epidermis. pilot demonstrated ability skin different age their coherence. offers new way analysis specially pediatric applications. Larger studies are required further interpret discrepancies variation described by works.